I joined the Cancer and Blood Diseases Institute (CBDI) in 2008 as an associate professor and medical director for Cincinnati Children’s Neuro-Oncology Program, comprising a state-of-the-art multidisciplinary program for children, and young adults with central nervous system malignancies and a large national referral base and a tightly integrated bench, translational and clinical research enterprise with particular strengths in tumor biology, cell signaling/target identification, and the clinical development of new agents. I am currently a full professor and the Marjory J. Johnson Endowed Chari in Brain Tumor Translational Research. From 2012-2016, I chaired the Pediatric Brain Tumor Consortium. I have chaired multiple national and institutional phase I, II and III clinical trials of new agents for CNS malignancies through Children’s Oncology Group (COG), Pediatric Brain Tumor Consortium (PBTC), Collaborative Ependymoma Research Network (CERN) and local studies. In September 2016, I became Chair of the CNS Committee of the Children’s Oncology Group. I have extensive experience in the development and execution of trials, translational research and helping guide the agenda for pediatric neuro-oncology clinical trials nationally.