Dr. Roussel obtained her PhD at the University of Sciences in Lille, France, and did her post-doctoral fellowship as a Fogarty International Fellow in the Laboratory of Tumor Virus Genetics at the National Cancer Institute in Bethesda, MD. She moved to St Jude Children’s Research Hospital (SJCRH) where she rose through the ranks and is now Full Member in the Department of Tumor Cell Biology and Full Professor in the Department of Molecular Sciences at the University of Tennessee. Dr. Roussel leads the Cancer Biology Program of the SJCRH Comprehensive Cancer Center since 2006 and holds the SJCRH Endowed Chair in Molecular Oncogenesis since 2007. Dr. Roussel is a member of several advisory boards, including the Board of Scientific Advisors to the NCI director, scientific review committees and she serves on several editorial boards. In 2011, she was elected to the American Academy of Arts and Sciences and was ranked as one of the top 50 French personalities in the USA. In 2017, she was awarded the Mentor of the Year.Her research interest covers many aspects of the regulation of cell proliferation from understanding mitogenic and apoptotic signals to G1 restriction point control and how they regulate the central nervous system. She published < 200 publications. In the past 15 years, Roussel has developed several mouse models and patient-derived xenografts of medulloblastoma to assess the role of targeted and non-targeted agents in pre-clinical trials that led to two ongoing clinical trials at SJCRH.